Corin In Floor Plate

Ono et al 2007.

Corin in floor plate.

Corin corin serine peptidase is a protein coding gene. Following intensive efforts since their discovery little more than 10 years ago cell replacement therapy using induced pluripotent stem ips cells i. Directed differentiation and purification of mesencephalic dopaminergic mesda neurons from stem cells are crucial issues for realizing safe and efficient cell transplantation therapies for parkinson s disease. Corin is a cardiac protease that regulates bp blood pressure by activating natriuretic peptides.

The improved mda differentiation protocols. Dean arnold corll december 24 1939 august 8 1973 was an american serial killer who abducted raped tortured and murdered at least 28 teenage boys and young men between 1970 and 1973 in houston texas he was aided by two teenaged accomplices david owen brooks and elmer wayne henley the crimes which became known as the houston mass murders came to light after henley fatally shot corll. We obtained urine and kidney. Similar results with regard to the expression of these markers were obtained with another ipsc line 404c2 figures s1d s1f.

In the present study we tested the hypothesis that corin may be present in human urine and that urinary corin levels may be altered in patients with kidney disease. For that purpose fluorescence activated cell sorting facs using antibodies for corin a floor plate fp marker 9 or alcam a central nervous system microvascular endothelium marker 10 have. Mda neural precursor cells facs sorted for the floor plate marker corin could rescue a macaque model of pd established by 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine mptp lesion 7. To confirm the potential of the differentiated cells to become midbrain da neurons the floating spheres were replated on.

The corin cells a floor plate marker emerged after day 10 and peaked around day 21 28. Recent animal studies identified corin expression in the kidney where it may regulate renal function. These international efforts are culminating in the first cell replacement therapy crt clinical trials for pd 9. Diseases associated with corin include preeclampsia eclampsia 5 and eclampsia among its related pathways are myometrial relaxation and contraction pathways and cardiac conduction gene ontology go annotations related to this gene include serine type endopeptidase activity and serine type exopeptidase activity.